Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp130 | Female Reproduction | ECE2018

Alterations in gonadotropin receptors and signal activation in granulosa lutein cells from women with polycystic ovary syndrome

Owens Lisa , Christopolous Georgios , Khanjani Shirin , Hardy Kate , Lavery Stuart , Franks Stephen , Hanyaloglu Aylin

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 5–10% of women of reproductive age. The underlying pathogenesis is complex and incompletely understood. There is evidence that gonadotropin and gonadotropin receptor action play a role in the pathogenesis of PCOS with genome wide association studies in PCOS also implicating altered gonadotropin action in the aetiology of PCOS. Furthermore, our recent studies have demonstrated that gonad...